Courtney Cox gets candid about health and the MTHFR gene


At 53, Courteney Cox is ready to talk about the past. But, it’s because she feels better than she ever has: her inner and outer health and beauty are finally in sinc, “Hollywood makes it hard; this business makes it harder. I grew up thinking appearance was the most important thing. That as long as I looked OK, I would be OK, which got me into trouble.” 1 Chasing the fountain of youth had consequences.

Though the road to acceptance wasn’t easy (especially in a town where it’s a no-no to admit you’ve had work done) Cox is reformed. She’s now “as natural” (she had all the fillers in her face dissolved) as she can be and looks amazing. Hindsight is 20/20 of course. Cox says she realizes she should have taken better care of her body earlier in life than she did, but it’s never too late to start.


In an interview with New Beauty, she said,

“Well, what would end up happening is that you go to a doctor who would say, ‘You look great, but what would help is a little injection here or filler there.’ So you walk out and you don’t look so bad and you think, no one noticed—it’s good. Then somebody tells you about another doctor: ‘This person’s amazing. They do this person who looks so natural.’ You meet them and they say, ‘You should just do this.’ The next thing you know, you’re layered and layered and layered. You have no idea because it’s gradual until you go, ‘Oh sh*t, this doesn’t look right.’ And it’s worse in pictures than in real life. I have one friend who was like, ‘Whoa, no more!’ I thought, I haven’t done anything in six months. I didn’t realize.”2

Also, about four years ago, Cox, who calls herself “a really good eater,” found out she had the MTHFR gene mutation (loads and loads of people do). To understand this mutation, check out the videos below:

Her doctor asked her to get tested because not only had she suffered multiple miscarriages, but her dad had died of rare cancer, and depression ran in her family. Her results showed that she had the worst version of the mutation leaving her body to methylate incorrectly.

So, armed with the information on what had been happening to her body, and how she could help herself, she changed her diet and lifestyle and now feels betters and has more energy:

“I used to get so tired and would literally crumble after I ate something. Now I give myself a shot of methylated B-12 daily. When I was pregnant, I took folic acid like you’re supposed to, but I learned later that it wasn’t good for me. I have to take a methylfolate and methylated B, and then I can absorb it.”

It’s a good idea that everyone gets tested for the MTHFR gene mutation, especially if these symptoms, from the three symptom areas, sound familiar 3:

 1. Central Nervous System disorders – some of these come from not having enough SAMe. SAMe is responsible for creating Serotonin & neurotransmitters responsible for mood, motivation, and to some degree energy levels.  If these neurotransmitters are low, then Depression is often the result, but even aggression and alcoholism are symptoms sometimes found in men.  Pregnant women may encounter extreme Post-partum depression. In addition, things like Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS (Irritable Bowel Syndrome), Memory loss with Alzheimer’s and Dementia as well as other psychiatric problems can be tied to this issue (OCD, Bipolar, Schizophrenia, and more). These challenges are sometimes associated more with the 1298 gene mutation. A clinical trial was done by Dr. Fava (July, 2011), and it showed that giving L-Methylfolate (specifically Metafolin®) found in the prescription ‘medical food’, [Deplin® is a registered trademark of Société des Products Nestlé S.A. and is under license by Nestlé Health Science-Pamlab, Inc.], was as effective as the top anti-depressant drugs available today (without all the side effects).

 2. Cardiovascular problems often occur when Homocysteine levels in the body are too high. Heart attack, Stroke, Blood Clots, Peripheral neuropathy, Anemia even Miscarriages, and Congenital birth defects can be related to this issue among other symptoms. These problems are typically more related to the 677-gene mutation but seem to be worse for people who have a double mutation (two copies of the 677 or two copies of the 1298). Some doctors think the worst combination is someone with one 677 variant and one 1298 variant (referred to as compound heterozygous).

 3. Environmental poisoning can increase when not enough Glutathione is present to detox the body. Glutathione is responsible for detoxifying the body of heavy metals, toxins, and BPAs, etc. that we encounter in the environment. Glutathione is our body’s most powerful antioxidant. When a body gets too burdened by heavy metals and toxins, a lot of unexpected health problems emerge. Some symptoms of this can be: Nausea, Diarrhea, Abdominal pain, Liver and Kidney dysfunction, Hypertension, Tachycardia, Pulmonary fibrosis, Asthma, Immune problems, Hair loss, Rashes and much more (as you can imagine).

For more information on the MTHFR gene mutation, click here.

It’s refreshing to see a woman in Hollywood admitting she’s made mistakes AND saying out loud, I’m not 20 anymore and things are going to “start sagging.” There are loads of things you can do to keep your body in top shape and take care of your skin but one of the most important things you can do is love yourself. Right where you are.

XO- Erin

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Erin Elizabeth


Erin Elizabeth is a long time activist with a passion for the healing arts, working in that arena for a quarter century. Her site is barely 4 years old, but cracked the top 20 Natural Health sites worldwide. She is an author, public speaker, and has recently done some TV and film programs for some of her original work which have attracted international media coverage. Erin was the recipient for the Doctors Who Rock "Truth in Journalism award for 2017. You can get Erin’s free e-book here and also watch a short documentary on how she overcame vaccine injuries, Lyme disease, significant weight gain, and more. Follow Erin on FacebookTwitter, and Instagram.

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Sources and References

  1. Yahoo! June 21, 2017.
  2. Yahoo! June 21, 2017.
  3. Methyl-life.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment.

  • When we eat glyphosate on food, it destroys or shikamate pathway of our microbial and impairs a gene on your glyoxylate metabolic process called GNMT which then shuts down methionine synthase. MTHFR resides in methionine synthase.
    Also know that before ever taking 5,10 methylenetetrahydro folate you must have magnesium. Folate is a sugar and there are several genes that synthesize folate on the pentose phosphate pathway. MTHFS, MTHFD1, MTHFD1L, MTHFD2 and DHFR. All these genes cofactors are magensium. So if you consume folate without magnesium in place, it is worthless. Magnesium is responsible for assimilating not only folate but fructose and ribose 5 phosphate/riboblavin 5 phosphate/b2 (b2 is a sugar) .
    Then knowing that if you are low on B2 (riboflavin 5 phosphate) or if you are high in b2 (if you are high in B2 this means you are ATP and/or magnesium deficient and ATP comes from minerals) that the MTHFR gene will be impaired even more! Because the cofactor for MTHFR is not 5,10 methylenetetrahydro folate but B2! And it is B2’s job to take 5 methyltetrafolate (from food) and NAD (a form of niacin) and convert them into 5,10 methylenetetrahydro folate and NADH (reduced niacin) on it’s own.
    Unfortunately you have 80% less conversion of 5 methyltetrahydrofolate to 5,10 methylenetetrahydrofolate when you are homozygous for MTHFR C677T and about 40% less converson when you are heterozygous for MTHFR C677T. Now MTHFR A1298C works totally opposite from C677T and is more of the B2 end to get folate to convert for fuel and glutathione production.
    Also GNMT which shuts down activity of MTHFR when B6 is missing or not working impairs MTHFR by impacting SAMe. So this tells us poor B6 activity is what keeps SAMe from not functioning. And MTHFR’s enzyme regulation is SAMe.
    So many people that have MTHFR need to focus on GNMT, methionine synthase, SAMe regulation by making sure B6 is functioning. Magnesium must be in place to synthesize the folate and then niacin has to be in place. And what form of niacin you will need and how much niacin you will need will depend on your gene COMT V158M and H62H. And people homozygous for COMT V158M and H62H need much less 5,10 methylenetetrahydro folate and more 5 methyltetrahydro folate. That is why homozygous COMTs will often have panic attacks when taking 5,10 methylenetetrahydro folate.
    Treating a SNP and treating an individual are two different things.
    Help heal and love